![]() Significant quantities of sulfadiazine can be absorbed following prolonged treatment of extensive burns. Systemic absorption of silver, resulting in argyria, can occur when silver sulfadiazine is applied to large area wound or over prolonged periods. Transient leukopenia does not usually require withdrawal of silver sulfadiazine, but blood counts should be monitored to ensure they return to normal within a few days. Sulfa medicines may cause liver problems in these infants. Use is not recommended in premature or newborn infants up to 2 months of age. Silver sulfadiazine may be absorbed following topical application and produce systemic effects similar to those of other sulfonamides. ![]() However, due to the hazards of sepsis in severe burns, the use of silver sulfadiazine in such patients must be determined individually. It is advised not to use silver sulfadiazine (SILVEDERMA) cream in patients sensitive to sulfonamides and in pregnant women. Sulfonamide treatment is usually contraindicated in premature or newborn infants during the first 2 months of life because of the risk of producing kernicterus for the same reason, they are generally contraindicated in women approaching term and in breast-feeding mothers. Silver sulfadiazine (SILVEDERMA) is contraindicated in patients who are hypersensitive to sulfonamides or to any other component of the preparation. Use and dose must be determined by the physician. Premature and newborn infants up to 2 months of age The drug should not be withdrawn from the therapeutic regimen as long as the possibility of infection exists, except when a significant adverse reaction occurs. It is recommended to apply hydrotherapy and mechanical debridement in patients with third-degree burns. Do not use two doses at once.ĭressings are unnecessary but covering with fine mesh gauze and bandage will be more comfortable to most patients. However, if it is almost time for the next dose, skip the missed dose and go back to your regular dosing schedule. If a dose is missed, apply it as soon as possible. Treatment must be continued until satisfactory healing is achieved or until the burn site is ready for grafting. However, silver sulfadiazine (SILVEDERMA) cream should be applied more frequently to burn areas in which the cream might be removed through involuntary movement of the patient. The cream is usually applied once or twice daily to a thickness of approximately 1/16 inch (1.5 mm). Measure the burn size by assuming the palm of the child’s hand is approximately 1 % of their body surface area, then estimate the number of “hands” needed to cover the burn.Īdults and children 2 months of age and older:Īfter cleaning and debridement of wound, apply the cream with a sterile gloved hand, to the burned surface with a thickness of 1 to 3 mm, assuring that all crevices of the irregular burn surface are treated. Measurement is performed in multiples of nine. The size of the burn is determined by the body-surface area affected. It is a sulfonamide that is used, in conjunction with debridement, as a 1% cream for the prevention and treatment of infection in severe burns. ![]() Silver sulfadiazine ( SILVEDERMA) cream is an antimicrobial agent for topical use. Up to about 10% of the sulfadiazine may be absorbed concentrations in blood of 10 to 20 mcg per mL have been reported, although higher concentrations may be achieved when extensive areas of the body are treated. Silver sulfadiazine slowly releases sulfadiazine when in contact with wound exudates. Silver sulfadiazine has a bactericidal action, in contrast to sulfadiazine, the silver salt acts primarily on the cell membrane and cell wall and its action is not antagonized by p-aminobenzoic acid (PABA). Silver sulfadiazine has broad antimicrobial activity against Gram-positive and Gram-negative bacteria including Pseudomonas aeruginosa, and some yeasts and fungi. Each gram of cream contains micronized silver sulfadiazine 1 mg. ![]()
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